Epidural blockade improves substrate utilization after surgery.

  title={Epidural blockade improves substrate utilization after surgery.},
  author={Th. Schricker and Linda J. Wykes and Federica Carli},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={279 3},
The purpose of this study was to test the hypothesis that epidural blockade with local anesthetic improves the anticatabolic effects of glucose after colorectal surgery. Sixteen patients were randomly assigned to undergo a 6-h stable isotope infusion study (3 h fasted, 3 h glucose infusion at 4 mg. kg(-1). min(-1)) on the second postoperative day with or without perioperative epidural blockade. Protein synthesis, breakdown and oxidation, and glucose production and clearance were assessed by L… CONTINUE READING


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