Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study.

@article{Ohtori2012EpiduralAO,
  title={Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study.},
  author={Seiji Ohtori and Masayuki Miyagi and Yawara Eguchi and Gen Inoue and Sumihisa Orita and Nobuyasu Ochiai and Shunji Kishida and Kazuki Kuniyoshi and Junichi Nakamura and Yasuchika Aoki and Tetsuhiro Ishikawa and Gen Arai and Hiroto Kamoda and Miyako Suzuki and Masashi Takaso and Takeo Furuya and Tomoaki Toyone and Kazuhisa Takahashi},
  journal={Spine},
  year={2012},
  volume={37 6},
  pages={
          439-44
        }
}
STUDY DESIGN Prospective randomized trial. OBJECTIVE To examine the effect of the tumor necrosis factor alpha (TNF-α) inhibitor, etanercept, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar spinal stenosis. SUMMARY OF BACKGROUND DATA TNF-α is thought to play a crucial role in the radicular pain caused by lumbar disc herniation and spinal stenosis. Intravenous infusion of infliximab for sciatica has been examined in 2 studies; however, the results… CONTINUE READING
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