Epidural Clonidine

@article{Patel1996EpiduralC,
  title={Epidural Clonidine},
  author={S. S. Patel and C. Dunn and H. M. Bryson},
  journal={CNS Drugs},
  year={1996},
  volume={6},
  pages={474-497}
}
  • S. S. Patel, C. Dunn, H. M. Bryson
  • Published 1996
  • Medicine
  • CNS Drugs
  • SynopsisClonidine is an established α2 adrenoceptor agonist with antihypertensive properties which, when administered epidurally, has an analgesic action that is largely mediated by α2 adrenoceptors in the dorsal horn of the spinal cord. After epidural administration, the drug undergoes rapid systemic absorption and is able to pass through the placenta.Datafrom clinical studies evaluating the efficacy of epidural clonidine indicate that it is a useful adjunct to opioid and/or local anaesthetic… CONTINUE READING

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