Epidural Clonidine

  title={Epidural Clonidine},
  author={Sanjay K. S. Patel and Christopher J. Dunn and Harriet M. Bryson},
  journal={CNS Drugs},
SynopsisClonidine is an established α2 adrenoceptor agonist with antihypertensive properties which, when administered epidurally, has an analgesic action that is largely mediated by α2 adrenoceptors in the dorsal horn of the spinal cord. After epidural administration, the drug undergoes rapid systemic absorption and is able to pass through the placenta.Datafrom clinical studies evaluating the efficacy of epidural clonidine indicate that it is a useful adjunct to opioid and/or local anaesthetic… Expand
6 Citations
Epidural Bolus Clonidine/Morphine Versus Epidural Patient-Controlled Bupivacaine/Sufentanil: Quality of Postoperative Analgesia and Cost-Identification Analysis
It is concluded that because of superior analgesia and reduced side effects at analogous costs, PCEA is preferable to the BOLUS technique for the treatment of postoperative pain. Expand
Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?
Antidepressants are analgesic in the absence or presence of depression. The underlying mechanisms probably involve a complex interplay between several neurotransmitter systems and neuroreceptors.Expand
Recent advances in the identification of a 1- and a 2-adrenoceptor subtypes: therapeutic implications
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ADHD With Comorbid Bipolar Disorders: A Systematic Review of Neurobiological, Clinical And Pharmacological Aspects Across The Lifespan.
A systematic review of the scientific literature on the neurobiological, clinical features and current pharmacological management of ADHD comorbid with BDs across the entire lifespan, with a major focus on the adulthood. Expand
Cleavage of 2‐(Arylamino)‐4,6‐dimethoxypyrimidines To Yield Arylguanidines
A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4,6-dimethoxypyrimidines, which were preparedExpand


Epidural Clonidine Treatment for Refractory Reflex Sympathetic Dystrophy
Transdermal clonidine has been demonstrated to produce analgesia in the area surrounding its application site in patients with SMP and indicates that extensive analgesia may be obtained by epidural administration. Expand
Epidural clonidine analgesia for intractable cancer pain: phase I.
The results suggest that epidurally administered clonidine may offer effective analgesia in patients with severe, intractable cancer pain. Expand
Epidural Clonidine Depresses Sympathetic Nerve Activity in Humans by a Supraspinal Mechanism
The comparable inhibition of resting sympathetic nerve activity, paralleled by a decrease in heart rate and blood pressure after both epidural and intramuscular clonidine, indicates that epiduralClonidine induces a supraspinally evoked general decrease in sympathetic outflow. Expand
Management of postoperative pain by continuous epidural infusion of analgesics.
Current studies suggest superior analgesia for the majority of surgical procedures with continuous epidural analgesia infusions compared with more traditional methods of providing analgesia. Expand
Hemodynamic and Analgesic Actions of Epidurally Administered Clonidine
These data support previous studies in animals and provide the scientific rationale for this novel analgesic therapy, and suggest the minimum effective CSF clonidine concentration for postoperative pain relief is 76 ± 15 ng/ml. Expand
Clonidine and or adrenaline decrease lignocaine plasma peak concentration after epidural injection.
The results show that, clonidine decreases lignocaine Cmax to the same extent as adrenaline. Expand
Epidural clonidine analgesia for intractable cancer pain
It is suggested that epidural clonidine may provide effective relief for intractable cancer pain, particular of the neuropathic type, in patients with neuropathic pain treated withClonidine rather than placebo. Expand
Clonidine combined with sufentanil and bupivacaine with adrenaline for obstetric analgesia.
The degree of motor block or the frequency of other side effects were not enhanced by clonidine, and there was no difference between the two groups in duration of analgesia after the first injection. Expand
Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section
Many authors have shown the analgesic efficacy of 150–800 μg of epidural clonidine in the postoperative period. Its use as an analgesic after caesarean section has recently been studied with higherExpand
Epidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study
Epidural clonidine 3 micrograms/kg epidurally seems to lack clinically important analgesic effects on severe postoperative pain, at least following thoracotomy. Expand