Epidural Clonidine

@article{Patel1996EpiduralC,
  title={Epidural Clonidine},
  author={Sanjay K. S. Patel and Christopher J. Dunn and Harriet M. Bryson},
  journal={CNS Drugs},
  year={1996},
  volume={6},
  pages={474-497}
}
SynopsisClonidine is an established α2 adrenoceptor agonist with antihypertensive properties which, when administered epidurally, has an analgesic action that is largely mediated by α2 adrenoceptors in the dorsal horn of the spinal cord. After epidural administration, the drug undergoes rapid systemic absorption and is able to pass through the placenta.Datafrom clinical studies evaluating the efficacy of epidural clonidine indicate that it is a useful adjunct to opioid and/or local anaesthetic… Expand
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References

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Epidural Clonidine Treatment for Refractory Reflex Sympathetic Dystrophy
TLDR
Transdermal clonidine has been demonstrated to produce analgesia in the area surrounding its application site in patients with SMP and indicates that extensive analgesia may be obtained by epidural administration. Expand
Epidural clonidine analgesia for intractable cancer pain: phase I.
TLDR
The results suggest that epidurally administered clonidine may offer effective analgesia in patients with severe, intractable cancer pain. Expand
Epidural Clonidine Depresses Sympathetic Nerve Activity in Humans by a Supraspinal Mechanism
TLDR
The comparable inhibition of resting sympathetic nerve activity, paralleled by a decrease in heart rate and blood pressure after both epidural and intramuscular clonidine, indicates that epiduralClonidine induces a supraspinally evoked general decrease in sympathetic outflow. Expand
Management of postoperative pain by continuous epidural infusion of analgesics.
TLDR
Current studies suggest superior analgesia for the majority of surgical procedures with continuous epidural analgesia infusions compared with more traditional methods of providing analgesia. Expand
Hemodynamic and Analgesic Actions of Epidurally Administered Clonidine
TLDR
These data support previous studies in animals and provide the scientific rationale for this novel analgesic therapy, and suggest the minimum effective CSF clonidine concentration for postoperative pain relief is 76 ± 15 ng/ml. Expand
Clonidine and or adrenaline decrease lignocaine plasma peak concentration after epidural injection.
TLDR
The results show that, clonidine decreases lignocaine Cmax to the same extent as adrenaline. Expand
Epidural clonidine analgesia for intractable cancer pain
TLDR
It is suggested that epidural clonidine may provide effective relief for intractable cancer pain, particular of the neuropathic type, in patients with neuropathic pain treated withClonidine rather than placebo. Expand
Clonidine combined with sufentanil and bupivacaine with adrenaline for obstetric analgesia.
TLDR
The degree of motor block or the frequency of other side effects were not enhanced by clonidine, and there was no difference between the two groups in duration of analgesia after the first injection. Expand
Ventilatory effects of epidural clonidine during the first 3 hours after caesarean section
Many authors have shown the analgesic efficacy of 150–800 μg of epidural clonidine in the postoperative period. Its use as an analgesic after caesarean section has recently been studied with higherExpand
Epidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study
TLDR
Epidural clonidine 3 micrograms/kg epidurally seems to lack clinically important analgesic effects on severe postoperative pain, at least following thoracotomy. Expand
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