Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864.

@article{Rudmann2004EpididymalAS,
  title={Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864.},
  author={Daniel G Rudmann and Mary Ellen Mcnerney and Stacey L VanderEide and Joyce K Schemmer and Robert R. Eversole and Steven L. Vonderfecht},
  journal={Toxicologic pathology},
  year={2004},
  volume={32 3},
  pages={326-32}
}
Repeat dose oral toxicity studies were conducted in rat and dog to assess the safety for human clinical testing of the potent dopamine D3 receptor antagonist, PNU-177864. Systemic phospholipidosis was the principal treatment-related change with epididymal epithelial cell phospholipidosis being the most prominent finding in rats and dogs. Epididymal… CONTINUE READING