Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.

  title={Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.},
  author={Erna Magn{\'u}sd{\'o}ttir and Sergey Kalachikov and Koji Mizukoshi and David Savitsky and Akemi Ishida-Yamamoto and Andrey A Panteleyev and K. Calame},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 38},
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves dramatic cell condensation before death. Using conditional gene deletion in mice, we identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer… CONTINUE READING


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