Epidermal sphingolipids: metabolism, function, and roles in skin disorders.

@article{Holleran2006EpidermalSM,
  title={Epidermal sphingolipids: metabolism, function, and roles in skin disorders.},
  author={Walter M. Holleran and Yutaka Takagi and Yoshikazu Uchida},
  journal={FEBS letters},
  year={2006},
  volume={580 23},
  pages={5456-66}
}
Mammalian epidermis produces and delivers large quantities of glucosylceramide and sphingomyelin precursors to stratum corneum extracellular domains, where they are hydrolyzed to corresponding ceramide species. This cycle of lipid precursor formation and subsequent hydrolysis represents a mechanism that protects the epidermis against potentially harmful effects of ceramide accumulation within nucleated cell layers. Prominent skin disorders, such as psoriasis and atopic dermatitis, have… CONTINUE READING

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