Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis

@inproceedings{Keymeulen2009EpidermalPG,
  title={Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis},
  author={Alexandra Van Keymeulen and Guilhem Mascr{\'e} and Khalil Kass Youseff and Itamar Harel and Cindy Michaux and Natalie de Geest and Caroline Szpalski and Youn{\`e}s Achouri and Wilhelm Bloch and Bassem A Hassan and C{\'e}dric Blanpain},
  booktitle={The Journal of cell biology},
  year={2009}
}
Merkel cells (MCs) are located in the touch-sensitive area of the epidermis and mediate mechanotransduction in the skin. Whether MCs originate from embryonic epidermal or neural crest progenitors has been a matter of intense controversy since their discovery >130 yr ago. In addition, how MCs are maintained during adulthood is currently unknown. In this study, using lineage-tracing experiments, we show that MCs arise through the differentiation of epidermal progenitors during embryonic… CONTINUE READING
87 Citations
41 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…