Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.

@article{Hansson2002EpidermalOO,
  title={Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.},
  author={Lennart Hansson and Assar B{\"a}ckman and Annelii Ny and Michael Edlund and Elisabeth Ekholm and Barbro Ekstrand Hammarstr{\"o}m and Jan T{\"o}rnell and Pia Wallbrandt and H{\aa}kan Wennbo and Torbj{\"o}rn Egelrud},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={118 3},
  pages={
          444-9
        }
}
Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis. Here is reported an increased epidermal expression of stratum corneum chymotryptic… CONTINUE READING
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