Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.

@article{Tarutani2013EpidermalHI,
  title={Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.},
  author={Masahito Tarutani and Kimiko Nakajima and Mikiro Takaishi and Kentaro Ohko and Shigetoshi Sano},
  journal={Journal of dermatological science},
  year={2013},
  volume={72 2},
  pages={
          110-5
        }
}
BACKGROUND Raf is one of the downstream effectors of Ras GTPases, and plays a key role in regulating cell proliferation and differentiation through the activation of MAPK. We have previously demonstrated that temporal induction of Raf in the epidermis of K14-Raf:ER transgenic mice results in epidermal hyperplasia resembling squamous cell carcinoma and psoriasis. It has been demonstrated that epidermal Stat3 activation is required for psoriasis development, since keratinocyte-specific Stat3… CONTINUE READING

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