Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems.

@article{Edmondson2003EpidermalHT,
  title={Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems.},
  author={Stephanie R. Edmondson and Susan P Thumiger and George Arthur Werther and Christopher J. Wraight},
  journal={Endocrine reviews},
  year={2003},
  volume={24 6},
  pages={737-64}
}
GH and IGF-I and -II were first identified by their endocrine activity. Specifically, IGF-I was found to mediate the linear growth-promoting actions of GH. It is now evident that these two growth factor systems also exert widespread activity throughout the body and that their actions are not always interconnected. The literature highlights the importance of the GH and IGF systems in normal skin homeostasis, including dermal/epidermal cross-talk. GH activity, sometimes mediated via IGF-I, is… CONTINUE READING
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