Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors.


MMP-7 is a member of the matrix metalloproteinase family and has been shown to be involved in early intestinal tumorigenesis. However, the factors which regulate MMP-7 gene transcription in the context of early colon cancer remain to be elucidated. Epidermal growth factor (EGF) and the EGF receptor have also been demonstrated to be important in the… (More)


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