Epidermal growth factor system regulates mucin production in airways.

  title={Epidermal growth factor system regulates mucin production in airways.},
  author={Kiyoshi Takeyama and Karim Dabbagh and Hana Lee and Carlos Agust{\'i} and James A. Lausier and Iris F. Ueki and K M Grattan and Jay A. Nadel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 6},
Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying mechanisms are unknown, and no effective therapy exists. Here we show that stimulation of epidermal growth factor receptors (EGF-R) by its ligands, EGF and transforming growth factor alpha (TGFalpha), causes MUC5AC expression in airway epithelial cells both in in vitro and in vivo. We found that a MUC5AC-inducing epithelial cell line, NCI-H292, expresses EGF-R constitutively… CONTINUE READING
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