Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

@article{Hepler1987EpidermalGF,
  title={Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.},
  author={John R Hepler and Norimichi Nakahata and Timothy W. Lovenberg and J Diguiseppi and Benjamin Herman and H. Shelton Earp and T. Kendall Harden},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 7},
  pages={2951-6}
}
Exposure of A431 human epidermoid carcinoma cells to epidermal growth factor (EGF), bradykinin, and histamine resulted in a time- and concentration-dependent accumulation of the inositol phosphates (InsP) inositol monophosphate, inositol bisphosphate, and inositol trisphosphate (InsP3). Maximal concentrations of EGF (316 ng/ml; approximately 50 nM), bradykinin (1 microM), and histamine (1 mM) resulted in 3-, 6-, and 3-fold increases, respectively, in the amounts of inositol phosphates formed… CONTINUE READING
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