Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling.

@article{Frey2004EpidermalGF,
  title={Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling.},
  author={Mark R Frey and Anastasia Golovin and David Brent Polk},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 43},
  pages={
          44513-21
        }
}
Members of the epidermal growth factor (EGF) family of ligands and their receptors regulate migration and growth of intestinal epithelial cells. However, our understanding of the signal transduction pathways determining these responses is incomplete. In this study we tested the hypothesis that p38 is required for EGF-stimulated intestinal epithelial monolayer restitution. EGF-stimulated migration in a wound closure model required continuous presence of ligand for several hours for maximal… CONTINUE READING
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