Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate

  title={Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate},
  author={Edward R Sherwood and Chung Ryul Lee},
  journal={World Journal of Urology},
Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFα) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predominant EGF-related growth factor in the normal prostate and in benign prostatic hyperplasia (BPH). Evidence indicates that EGF and TGFα are important for maintainence of the structural… CONTINUE READING
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