Epidermal growth factor receptors: critical mediators of multiple receptor pathways.

@article{Hackel1999EpidermalGF,
  title={Epidermal growth factor receptors: critical mediators of multiple receptor pathways.},
  author={P O Hackel and Esther Zwick and Norbert Prenzel and Axel Ullrich},
  journal={Current opinion in cell biology},
  year={1999},
  volume={11 2},
  pages={184-9}
}
Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified. 
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