Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis.

@article{Xue2006EpidermalGF,
  title={Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis.},
  author={Chengsen Xue and Jeffrey B. Wyckoff and Fubo Liang and Mazen Sidani and Stefania Violini and Kun-Lin Tsai and Zhong-Yin Zhang and Erik Sahai and John S Condeelis and Jeffrey E Segall},
  journal={Cancer research},
  year={2006},
  volume={66 1},
  pages={192-7}
}
Although overexpression of the epidermal growth factor receptor (EGFR; ErbB1) has been correlated with poor prognosis in breast and other cancers, clinical trials of ErbB1 inhibitors have shown limited efficacy in inhibiting tumor proliferation. To evaluate other possible roles of ErbB1 in tumor malignancy besides proliferation, we have developed a series of tools for analysis of intravasation. Overexpression of ErbB1 in MTLn3 mammary adenocarcinoma cells results in increased intravasation and… CONTINUE READING
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A critical step in metastasis: in vivo analysis of Cancer

  • JB Wyckoff, JG Jones, JS Condeelis, JE. Segall
  • Research Cancer Res
  • 2006
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Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis

  • C Xue, J Wyckoff, +7 authors JE Segall
  • Cancer Res
  • 2006

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