Epidermal growth factor receptor mutations in lung cancers.

  title={Epidermal growth factor receptor mutations in lung cancers.},
  author={Yasushi Yatabe and Tetsuya Mitsudomi},
  journal={Pathology international},
  volume={57 5},
In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sheds light on significant oncological properties as well as the clinical relevance of this mutation, which could be applicable to other malignancies. The EGFR mutations are… CONTINUE READING


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