Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology.

@article{Jnne2005EpidermalGF,
  title={Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology.},
  author={Pasi Antero J{\"a}nne and Jeffrey A. Engelman and Bruce Evan Johnson},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 14},
  pages={3227-34}
}
The epidermal growth factor receptor (EGFR) has emerged as an attractive therapeutic target for patients with non-small-cell lung cancer (NSCLC). However, despite its almost universal presence in NSCLC tumors, therapeutic inhibition of EGFR has resulted in significant tumor regressions in only 10% to 20% of patients. Several investigations over the last 12 months have uncovered somatic mutations in EGFR that underlie the sensitivity to EGFR inhibitors. NSCLC tumors and cell lines with EGFR… CONTINUE READING
150 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 150 extracted citations

Similar Papers

Loading similar papers…