Epidermal growth factor receptor mutation testing in the care of lung cancer patients.

@article{Sequist2006EpidermalGF,
  title={Epidermal growth factor receptor mutation testing in the care of lung cancer patients.},
  author={Lecia V Sequist and Victoria A. Joshi and Pasi Antero J{\"a}nne and Daphne W Bell and Panos H Fidias and Neal I Lindeman and David N Louis and Jeffrey C. Lee and Eugene Jerome Mark and Janina J Longtine and Peter C. Verlander and Raju Kucherlapati and Matthew Meyerson and Daniel A. Haber and Bruce Evan Johnson and Tom J. Lynch},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 14 Pt 2},
  pages={4403s-4408s}
}
As the literature about epidermal growth factor receptor (EGFR) mutations grows and screening for mutations becomes increasingly integrated into clinical care, it is important to examine how best to do somatic mutational analyses and how best to use the test results in clinical decision making. We began offering mutation screening by comprehensive direct sequence analysis of exons 18 to 24 of the tyrosine kinase domain of EGFR in August 2004 as part of clinical cancer care and protocol therapy… CONTINUE READING

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