Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

@article{Meyers1986EpidermalGF,
  title={Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.},
  author={Marilyn B Meyers and Vincent J. Merluzzi and Barbara A. Spengler and June L. Biedler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 15},
  pages={5521-5}
}
Multidrug-resistant sublines of Chinese hamster lung and mouse tumor cells selected for high levels of resistance to vincristine or actinomycin D have increased numbers of epidermal growth factor (EGF) receptors compared to control cells. Evidence for this increase was found in six of six resistant cell lines with the use of receptor binding or immunoprecipitation techniques. Levels of 125I-labeled EGF binding to intact actinomycin D-resistant cells derived from DC-3F or CLM-7 Chinese hamster… CONTINUE READING

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