Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.

@article{Yamashita2012EpidermalGF,
  title={Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.},
  author={Michifumi Yamashita and Saurabh Chattopadhyay and Volker Fensterl and Paramananda Saikia and Jaime L. Wetzel and Ganes C Sen},
  journal={Science signaling},
  year={2012},
  volume={5 233},
  pages={ra50}
}
Toll-like receptors (TLRs) recognize specific microbial products and elicit innate immune signals to activate specific transcription factors that induce protective proteins, such as interferon. TLR3 is localized to endosomes and recognizes double-stranded RNA (dsRNA), which is generated by virally infected or apoptotic cells. TLR3 has been genetically linked to several human diseases, including some without viral etiology. Unlike other TLRs, TLR3 requires phosphorylation of two specific… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 40 references

Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling

M. Yamashita, S. Chattopadhyay, +3 authors G. C. Sen
Sci. Signal. 5, • 2012

G.C.S. analyzed the data and interpreted the results; and M.Y. and G.C.S. wrote the manuscript. Competing interests: The authors declare that they have no competing interests

J.L.W
Submitted 3 October 2011 Accepted • 2012

Toll - like receptors and their crosstalk with other innate receptors in infection and

K. A. Fitzgerald Severa
IMMUNITY • 2011

Unexpected protective role for Toll-like receptor 3 in the arterial wall.

Proceedings of the National Academy of Sciences of the United States of America • 2011

Endosomes: a legitimate platform for the signaling train.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Epstein - Barr virus ( EBV ) – encoded small RNA is released from EBV - infected cells and activates signaling from Toll - like receptor 3

K. Yamada, A. Takeda, +18 authors J. Ambati
J . Exp . Med . • 2009

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