Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

Abstract

The aberrant growth of head and neck squamous cell carcinoma (HNSCC) is often associated with the constitutive activation of signal-transducer-and-activator-of-transcription-3 (STAT3), which is believed to result from the persistent stimulation of EGF receptors that are highly expressed in squamous cell carcinoma (SCC) cells. To investigate the mechanism… (More)

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@article{Sriuranpong2003EpidermalGF, title={Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.}, author={Virote R Sriuranpong and Jong In Park and Panomwat Amornphimoltham and Vyomesh Patel and Barry D. Nelkin and J. Silvio Gutkind}, journal={Cancer research}, year={2003}, volume={63 11}, pages={2948-56} }