Epidermal growth factor receptor in synaptic fractions of the rat central nervous system.

@article{Fandez1992EpidermalGF,
  title={Epidermal growth factor receptor in synaptic fractions of the rat central nervous system.},
  author={Victor Fa{\'u}ndez and Raul Krauss and Loreto Holuigue and Jorge Garrido and Adriana Vilchis Gonzalez},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 28},
  pages={20363-70}
}
Functional relationships between epidermal growth factor (EGF) and neural tissues have of late attracted increasing interest. However, in spite of reported EGF effects on neurons, the expression of the EGF receptor (EGF-R) has not yet been unambiguously demonstrated in these cells. This 170-kDa protein bears an intracellular tyrosine kinase domain in which activity is ligand-dependent. We give definitive evidence here for its presence in neonatal and adult rat neurons showing also, for the… CONTINUE READING

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