Epidermal growth factor receptor imaging in human head and neck cancer xenografts

@article{vanDijk2015EpidermalGF,
  title={Epidermal growth factor receptor imaging in human head and neck cancer xenografts},
  author={Laura K van Dijk and Otto C Boerman and Johannes H.A.M. Kaanders and Johan Bussink},
  journal={Acta Oncologica},
  year={2015},
  volume={54},
  pages={1263 - 1267}
}
ABSTRACT Molecular imaging of specific biomarkers can have prognostic, predictive or monitoring value in head and neck squamous cell carcinoma (HNSCC). The epidermal growth factor receptor (EGFR) is involved in various radiation resistance mechanisms as it steers the pathways related to DNA damage repair, proliferation, hypoxia and apoptosis. Radiolabeled labeled F(ab’)2 fragments of the EGFR antibody cetuximab can be applied for non-invasive imaging of this receptor. Preclinical studies have… 

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