Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation.

@article{Zhang2005EpidermalGF,
  title={Epidermal growth factor receptor gene polymorphisms predict pelvic recurrence in patients with rectal cancer treated with chemoradiation.},
  author={Wu Zhang and David J. M. Park and Bo Lu and Dong Yun Yang and Michael A. Gordon and Susan Groshen and Jim Yun and Oliver A. Press and Daniel Vallboehmer and Katrin E Rhodes and H. P. Lenz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 2 Pt 1},
  pages={600-5}
}
An association between epidermal growth factor receptor (EGFR) signaling pathway and response of cancer cells to ionizing radiation has been reported. Recently, a polymorphic variant in the EGFR gene that leads to an arginine-to-lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified. The variant EGFR (HER-1 497K) may lead to attenuation in ligand binding, growth stimulation, tyrosine kinase activation, and induction of proto-oncogenes myc… CONTINUE READING

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ArginineNo subtypeLysine
Recently , a polymorphic variant in the EGFR gene that leads to an arginine - to - lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified .
LysineNo subtypeArginine
Recently , a polymorphic variant in the EGFR gene that leads to an arginine - to - lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified .
In the current pilot study , we assessed both polymorphisms in 59 patients with locally advanced rectal cancer treated with adjuvant or neoadjuvant chemoradiation therapy using PCR - RFLP and a 5'-end [ gamma-(33)P]ATP - labeled PCR protocol .
In the current pilot study , we assessed both polymorphisms in 59 patients with locally advanced rectal cancer treated with adjuvant or neoadjuvant chemoradiation therapy using PCR - RFLP and a 5'-end [ gamma-(33)P]ATP - labeled PCR protocol .
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