Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial.

@article{Bentzen2005EpidermalGF,
  title={Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial.},
  author={S\oren M\oller Bentzen and Beste M Atasoy and Frances M Daley and Stanley Dische and Paul I Richman and Michele I Saunders and Klaus R{\"u}diger Trott and George D. Wilson},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 24},
  pages={5560-7}
}
PURPOSE Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy for head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) is a key controller of cellular proliferation in HNSCC, which stimulated the current study to look for a direct link between EGFR status and a possible clinical advantage of accelerated radiotherapy. PATIENTS AND METHODS Immunohistochemical staining for EGFR was performed in 304 patients with… CONTINUE READING
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