Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma.

@article{Valsecchi2012EpidermalGF,
  title={Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma.},
  author={Matias E. Valsecchi and Mary McDonald and Jonathan R. Brody and Terry Hyslop and Boris Freydin and Charles J Yeo and Charalambos C. Solomides and Stephen C. Peiper and Agnieszka K. Witkiewicz},
  journal={Cancer},
  year={2012},
  volume={118 14},
  pages={3484-93}
}
BACKGROUND The aim of this study was to evaluate the expression of epidermal growth factor receptor (EGFR) and insulinlike growth factor 1 receptor (IGF-1R) proteins and IGF-1R gene copy numbers in pancreatic ductal adenocarcinoma in relation to patients' characteristics and prognosis. METHODS Immunohistochemical staining was performed on formalin-fixed paraffin-embedded tissue derived from tumor specimens recovered during surgery. Slides were evaluated for membranous EGFR and IGF-1R staining… CONTINUE READING
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