Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

@article{Bachoo2002EpidermalGF,
  title={Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.},
  author={Robert M. Bachoo and Elizabeth A. Maher and Keith L Ligon and Norman E Sharpless and Suzanne S Chan and Mingjian James You and Yi Tang and Jessica DeFrances and Elizabeth H Stover and Ralph Weissleder and David H Rowitch and David N Louis and Ronald A DePinho},
  journal={Cancer cell},
  year={2002},
  volume={1 3},
  pages={
          269-77
        }
}
Ink4a/Arf inactivation and epidermal growth factor receptor (EGFR) activation are signature lesions in high-grade gliomas. How these mutations mediate the biological features of these tumors is poorly understood. Here, we demonstrate that combined loss of p16(INK4a) and p19(ARF), but not of p53, p16(INK4a), or p19(ARF), enables astrocyte dedifferentiation in response to EGFR activation. Moreover, transduction of Ink4a/Arf(-/-) neural stem cells (NSCs) or astrocytes with constitutively active… CONTINUE READING

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