Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation.

@article{Ravid2002EpidermalGF,
  title={Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation.},
  author={Tommer Ravid and Colleen A. Sweeney and Peter Gee and Kermit L. Carraway and Tzipora Goldkorn},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={31214-9}
}
Activation of the epidermal growth factor (EGF) receptor by its ligand, EGF, rapidly enhances receptor internalization and degradation, which desensitizes receptor signaling. In contrast, we have shown previously that exposure to oxidative stress in the form of hydrogen peroxide (H(2)O(2)) activated the EGF receptor but that the levels of activated receptors did not decline, which resulted in prolonged receptor signaling. This study provides mechanistic insights into these different modes of… CONTINUE READING

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