Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.

@article{Voldborg1997EpidermalGF,
  title={Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials.},
  author={Bj\orn Voldborg and Lars Damstrup and Mogens Spang-Thomsen and Hans Skovgaard Poulsen},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={1997},
  volume={8 12},
  pages={1197-206}
}
The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intracellular region of the receptor. This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth, DNA synthesis and the expression of oncogenes… CONTINUE READING
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Oncoprotein networks

  • T Hunter
  • Cell
  • 1997

Oncoprotein networks. Cell

  • T. Hunter
  • 1997
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