Epidermal growth factor promotes chick embryonic angiogenesis.

  title={Epidermal growth factor promotes chick embryonic angiogenesis.},
  author={Raj A Stewart and Jay Nelson and Darren J. Wilson},
  journal={Cell biology international reports},
  volume={13 11},
The response of the early extraembryonic vasculature to epidermal growth factor (EGF) was studied. Millipore filter discs containing 10ng-1 microgram of EGF were placed onto the advancing edge of the area vasculosa of 3-day chick embryos, and the effect examined macroscopically and histologically 24 hours after disc application. The capillary density at the site of application increased significantly, and the effect was seen to be dose-dependent; a similar but more marked response was observed… CONTINUE READING