Epidermal growth factor induces oxidative neuronal injury in cortical culture.

@article{Cha2000EpidermalGF,
  title={Epidermal growth factor induces oxidative neuronal injury in cortical culture.},
  author={Yoo K Cha and Yong Ho Kim and Young Hwan Ahn and Jae Young Koh},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 1},
  pages={298-303}
}
Recently, we have demonstrated that certain neurotrophic factors can induce oxidative neuronal necrosis by acting at the cognate tyrosine kinase-linked receptors. Epidermal growth factor (EGF) has neurotrophic effects via the tyrosine kinase-linked EGF receptor (EGFR), but its neurotoxic potential has not been studied. Here, we examined this possibility in mouse cortical culture. Exposure of cortical cultures to 1-100 ng/ml EGF induced gradually developing neuronal death, which was complete in… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Electron microscopic findings of EGF - induced neuronal death were consistent with necrosis ; severe mitochondrial swelling and disruption of cytoplasmic membrane occurred , whereas nuclei appeared relatively intact .
Electron microscopic findings of EGF - induced neuronal death were consistent with necrosis ; severe mitochondrial swelling and disruption of cytoplasmic membrane occurred , whereas nuclei appeared relatively intact .
A p38 mitogen - activated protein kinase inhibitor ( SB203580 ) or glutamate antagonists ( MK-801 and 6-cyano-7-nitroquinoxaline-2,3-dione ) showed no protective effect .
All Topics