Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta.

@article{Morrish1987EpidermalGF,
  title={Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta.},
  author={Donald W. Morrish and Damyanti Bhardwaj and Laith Dabbagh and Halyna Marusyk and O. Siy},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1987},
  volume={65 6},
  pages={1282-90}
}
Human trophoblast differentiates by the fusion of cytotrophoblasts to form syncytiotrophoblast. To determine factors controlling this process, the effects of epidermal growth factor (EGF) on trophoblast differentiation were studied using long term serum-free culture of isolated trophoblast. Only trophoblast was present in the cultures, as demonstrated by positive immunoperoxidase staining with beta hCG, cytokeratin, and trophoblast-specific H315 monoclonal antisera and by the absence of… CONTINUE READING

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