Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.

@article{Tanabe2008EpidermalGF,
  title={Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.},
  author={K. Tanabe and A. Lemoine and D. Finkelstein and H. Kawasaki and T. Fujii and R. Chung and G. Lauwers and Y. Kulu and A. Muzikansky and D. Kuruppu and M. Lanuti and Jonathan M. Goodwin and D. Azoulay and B. Fuchs},
  journal={JAMA},
  year={2008},
  volume={299 1},
  pages={
          53-60
        }
}
CONTEXT Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. OBJECTIVE To assess the relationship among human EGF gene single-nucleotide polymorphism, EGF expression, and risk of hepatocellular carcinoma. DESIGN, SETTING, AND PARTICIPANTS Molecular mechanisms linking the 61*G allele polymorphism to EGF expression were examined in human hepatocellular carcinoma cell… Expand

Paper Mentions

Observational Clinical Trial
To analyze specific angiogenic, inflammatory and immune profiles in hepatocellular carcinoma patients who undergo radioembolization.  
ConditionsHepatocellular Carcinoma
InterventionOther
A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients
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EGF gene polymorphism (GG genotype) had a significant risk of HCC development in cirrhotic patients, confirmed by increased EGF expression in liver tumor tissue from HCC patients. Expand
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The rs11569017 T allele was associated with susceptibility to HBV-related HCC, and was found to be associated with the growth of the embryo, tissue repairing, and tumorigenesis. Expand
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The EGF genotype G/G is associated with increased risk for HCC; differences in its frequency among black and white subjects might account for differences in HCC incidence between these groups. Expand
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The data suggests that the EGF gene may play a role in the development of ESCC in a Chinese population, and interindividual variations in EGF production were genetically contributed to EGF +61 G/A polymorphism. Expand
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This study suggests that EGF +61 GG genotype is associated with a higher risk of chronic HBV-infected HCC in the Chinese population. Expand
Genetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies
TLDR
Non-Asians in Los Angeles who possessed at least one copy of the high activity 61*G allele of the EGF gene showed a statistically non-significant, 78% increased risk of HCC compared with those possessing the E GF A/A genotype. Expand
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Epidermal Growth Factor Gene Polymorphism in Egyptian Patients with Hepatocellular carcinoma related to Hepatitis C
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EGF gene polymorphism 61*G was dominant in HCC patients and the increased concentration of EGF was associated with G/G genotype, with high statistical significance between the studied groups regarding number and percentage. Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Association between functional polymorphism in EGF gene and malignant melanoma
TLDR
It is suggested that high EGF production might be important in the development of malignant melanoma. Expand
EGF gene polymorphism and the risk of incident primary melanoma.
TLDR
Evidence against a strong association between EGF 61*G and melanoma is provided and the potential utility of case-case designs for evaluating the role of single nucleotide polymorphisms and cancer is demonstrated. Expand
Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours
TLDR
This study provided new information on the tumour stage-dependent network of EGF-regulated genes, and identified candidate genes linked to tumorigenes and progression of disease. Expand
A Functional Polymorphism in the EGF Gene Is Found with Increased Frequency in Glioblastoma Multiforme Patients and Is Associated with More Aggressive Disease
TLDR
Patients with the GA or GG genotype have higher tumoral levels of EGF, irrespective of EGFR status, that they are more likely to recur after surgery, and that they have a statistically significant shorter overall progression-free survival than patients with the AA genotype. Expand
Expression of Epidermal Growth Factor and Its Receptor in Cirrhotic Liver Disease
TLDR
Results indicate that EGF upregulation is a characteristic of cirrhotic liver disease and suggest that persistent de novo ligand synthesis and its signaling contribute to an autocrine-mediated hepatocyte proliferation within the regenerative nodule. Expand
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
TLDR
The blockade of EGFR activity by gefitinib has an antitumoral effect on the development of HCC in DEN‐exposed rats, suggesting that it may provide benefit for the chemoprevention of H CC. Expand
The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
TLDR
It is suggested that the MTHFR CC genotype increases the risk to develop HCC in patients who consume a high alcohol diet. Expand
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
TLDR
A subgroup of patients with non-small-cell lung cancer have specific mutations in the EGFR gene which correlate with clinical responsiveness to the tyrosine kinase inhibitor gefitinib, and these mutations lead to increased growth factor signaling and confer susceptibility to the inhibitor. Expand
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
TLDR
It is demonstrated that EGFR active site mutants are oncogenic, and treatment of lung cancers harboring EGFR exon 20 insertions may require the development of alternative kinase inhibition strategies. Expand
EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER
TLDR
The results suggest that the presence of EGF receptors is associated with metastatic potential and that the growth of a proportion of poor-prognosis oestrogen-receptor-negative tumours may be regulated by peptide growth factors interacting with the EGF receptor. Expand
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