Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.

  title={Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.},
  author={T J Velu and Laura Beguinot and William C. Vass and Mark C. Willingham and Glenn T. Merlino and Ira Pastan and Douglas R Lowy},
  volume={238 4832},
The epidermal growth factor (EGF) receptor gene EGFR has been placed in a retrovirus vector to examine the growth properties of cells that experimentally overproduce a full-length EGF receptor. NIH 3T3 cells transfected with the viral DNA or infected with the corresponding rescued retrovirus developed a fully transformed phenotype in vitro that required both functional EGFR expression and the presence of EGF in the growth medium. Cells expressing 4 x 10(5) EGF receptors formed tumors in nude… CONTINUE READING

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