Epidermal growth factor-dependent phosphorylation of lipocortin

  title={Epidermal growth factor-dependent phosphorylation of lipocortin},
  author={Robert Blake Pepinsky and Lesley K. Sinclair},
Lipocortin-like proteins are a family of steroid-induced inhibitors of phospholipase activity with potential anti-inflammatory activity (for reviews see refs 1, 2). Related proteins have been detected in a variety of tissues and species3–7. The best characterized form is a protein of relative molecular mass (Mr)∼40,000 (40K), which is phosphorylated in vivo by protein tyrosine kinases and by protein serine-threonine kinases8,9. It has been proposed that the phospholipase inhibitory activity of… CONTINUE READING
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