Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor.

@article{Winkler1989EpidermalGF,
  title={Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor.},
  author={Marjorie E. Winkler and Lourdes O'Connor and Marcy D. Winget and Brian M. Fendly},
  journal={Biochemistry},
  year={1989},
  volume={28 15},
  pages={6373-8}
}
Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) compete with each other for binding to the EGF receptor. These two growth factors have similar actions, but there are distinguishable differences in their biological activities. It has never been clear how this one receptor can mediate different responses. A monoclonal antibody to the EGF receptor (13A9) has been identified which has only small effects on the binding of EGF to the EGF receptor, but which has very… CONTINUE READING