Epidermal growth factor and the kidney.

  title={Epidermal growth factor and the kidney.},
  author={David A. Fisher and Eduardo Salido and Luciano Barajas},
  journal={Annual review of physiology},
Current information indicates that the mammalian kidney is a significant site of EGF synthesis, second only to the salivary gland in the rodent and probably exceeding most other tissues in the human species. The prepro EGF mRNA is localized to the cells of the TALH and the DCT. The EGF mRNA transcript in kidney is similar to that in salivary gland; the molecular mass of the prepro EGF protein in kidney approximates 130,000 kDa. Several EGF peptides are excreted in urine, including 6000… CONTINUE READING
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