Epidermal growth factor and prostaglandin E(2) accelerate mucosal recovery from stress-induced gastric lesions via inhibition of apoptosis.

@article{Konturek2001EpidermalGF,
  title={Epidermal growth factor and prostaglandin E(2) accelerate mucosal recovery from stress-induced gastric lesions via inhibition of apoptosis.},
  author={Peter C. Konturek and Tomasz Brzozowski and Alexandra Duda and Sławomir Kwiecień and Stefan L{\"o}ber and Artur Dembiński and Eckhart Georg Hahn and Stanisław Jan Konturek},
  journal={Journal of physiology, Paris},
  year={2001},
  volume={95 1-6},
  pages={361-7}
}
The repair of damaged gastric mucosa is a complex process involving prostaglandins (PG) and mucosal growth factors such as epidermal growth factor (EGF). Recently, we postulated that the increased occurrence of apoptosis in the gastric epithelium might be of pathophysiological importance in the development of stress lesions. The aim of the present study was to assess the effect of the pretreatment of rats, exposed to 3.5 h of water immersion and restraint stress (WRS), with EGF and PG (16,16… CONTINUE READING
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