Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.

@article{Lax1991EpidermalGF,
  title={Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.},
  author={Irit Lax and Alok K Mitra and Christina P Ravera and D R Hurwitz and Menachem Rubinstein and Axel Ullrich and Robert Michael Stroud and Joseph Schlessinger},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 21},
  pages={13828-33}
}
Ligand-induced oligomerization is a universal phenomenon among growth factor receptors. Although the mechanism involved is yet to be defined, much evidence indicates that receptor oligomerization plays a crucial role in receptor activation and signal transduction. Here we show that epidermal growth factor (EGF) is able to stimulate the oligomerization of a recombinant, soluble, extracellular ligand-binding domain of EGF receptor. Covalent cross-linking experiments, analysis by sodium dodecyl… CONTINUE READING

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