Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis

@inproceedings{Garay2015EpidermalGF,
  title={Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis},
  author={Camilo Garay and Gurjeet Judge and Stefanie Lucarelli and Stephen Bautista and Rohan Pandey and Tanveer Singh and Costin N Antonescu and Jean Gruenberg},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of cell survival and metabolism. Concomitantly, ligand-bound EGFR is incorporated into clathrin-coated pits--membrane structures containing clathrin and other proteins--eventually leading to receptor internalization. Whether clathrin might regulate EGFR signaling at the plasma membrane before vesicle scission is poorly understood. We compared the effect of… CONTINUE READING
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