Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells

@article{Lee1978EpidermalGF,
  title={Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells},
  author={L S Lee and I. Bernard Weinstein},
  journal={Nature},
  year={1978},
  volume={274},
  pages={696-697}
}
STUDIES on the action of the tumour-promoting compound 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and related plant diterpenes, in cell culture systems have revealed several unusual biological properties1–3. These include the induction of plasminogen activator production2 as well as several other phenotypic changes resembling those seen in cells transformed by chemical carcinogens or viruses1. Furthermore, these compounds are extremely potent inhibitors of several types of terminal… CONTINUE READING

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