Epidermal dystrophy and actinic keratoses in psoriasis patients following oral psoralen photochemotherapy (PUVA). Follow-up study.

@article{Abel1982EpidermalDA,
  title={Epidermal dystrophy and actinic keratoses in psoriasis patients following oral psoralen photochemotherapy (PUVA). Follow-up study.},
  author={Elizabeth A. Abel and Alison J. Cox and Eugene M. Farber},
  journal={Journal of the American Academy of Dermatology},
  year={1982},
  volume={7 3},
  pages={333-40}
}
Focal dystrophy of epidermal cells, which was initially reported in 19 of 37 patients with psoriasis who had been treated with psoralen and ultraviolet A (PUVA), has now been observed in more than half of 70 patients 1 year or more following onset of PUVA therapy. These dystrophic changes, which are similar to those found in actinic keratoses, were present in clinically uninvolved skin of sunlight-protected and sunlight-exposed areas. Control biopsies obtained prior to PUVA therapy of non-sun… CONTINUE READING