Epidermal barriers.

@article{Natsuga2014EpidermalB,
  title={Epidermal barriers.},
  author={Ken Natsuga},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2014},
  volume={4 4},
  pages={
          a018218
        }
}
The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors. This review illustrates human diseases (ichthyoses) and animal models in which the epidermal barrier is disrupted or dysfunctional at steady… CONTINUE READING
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