Epidermal T cells and wound healing.

  title={Epidermal T cells and wound healing.},
  author={Wendy L. Havran and Julie Marie Jameson},
  journal={Journal of immunology},
  volume={184 10},
The murine epidermis contains resident T cells that express a canonical gammadelta TCR. These cells arise from fetal thymic precursors and use a TCR that is restricted to the skin in adult animals. These cells assume a dendritic morphology in normal skin and constitutively produce low levels of cytokines that contribute to epidermal homeostasis. When skin is wounded, an unknown Ag is expressed on damaged keratinocytes. Neighboring gammadelta T cells then round up and contribute to wound healing… CONTINUE READING