Epidermal Langerhans cells: from neurons to nature's adjuvants.


Once obscure cells of interest to only a few dermatologists, LCs have become perhaps the best studied of all the nonlymphoid DCs. Seminal studies carried out by Steinman and co-workers over a number of years have demonstrated that interdigitating DCs are required for the priming of naive T cells in vivo and that LCs (and presumably other DCs) are precursors… (More)