Epidermal Iontophoresis: II. Application of the Ionic Mobility-Pore Model to the Transport of Local Anesthetics

@article{Lai1998EpidermalII,
  title={Epidermal Iontophoresis: II. Application of the Ionic Mobility-Pore Model to the Transport of Local Anesthetics},
  author={Pamela M. Lai and Michael S. Roberts},
  journal={Pharmaceutical Research},
  year={1998},
  volume={15},
  pages={1579-1588}
}
Purpose. An in vitro study was carried out to determine the iontophoretic permeability of local anesthetics through human epidermis. The relationship between physicochemical structure and the permeability of these solutes was then examined using an ionic mobility-pore model developed to define quantitative relationships. Methods. The iontophoretic permeability of both ester-type anesthetics (procaine, butacaine, tetracaine) and amide-type anesthetics (prilocaine, mepivacaine, lidocaine… CONTINUE READING

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