Epidermal Growth Factor and Membrane Trafficking

@article{Barbieri2000EpidermalGF,
  title={Epidermal Growth Factor and Membrane Trafficking},
  author={M A Barbieri and Richard L. Roberts and Aysel Gumusboga and Hilary Highfield and Carmen Alvarez-Dominguez and Alan Wells and Philip D. Stahl},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={539 - 550}
}
Activated epidermal growth factor receptors recruit various intracellular proteins leading to signal generation and endocytic trafficking. Although activated receptors are rapidly internalized into the endocytic compartment and subsequently degraded in lysosomes, the linkage between signaling and endocytosis is not well understood. Here we show that EGF stimulation of NR6 cells induces a specific, rapid and transient activation of Rab5a. EGF also enhanced translocation of the Rab5 effector… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 65 CITATIONS, ESTIMATED 60% COVERAGE

108 Citations

0510'01'04'08'12'16
Citations per Year
Semantic Scholar estimates that this publication has 108 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Similar Papers

Loading similar papers…