Epidermal Growth Factor Signalling Controls Myosin II Planar Polarity to Orchestrate Convergent Extension Movements during Drosophila Tubulogenesis

@inproceedings{Saxena2014EpidermalGF,
  title={Epidermal Growth Factor Signalling Controls Myosin II Planar Polarity to Orchestrate Convergent Extension Movements during Drosophila Tubulogenesis},
  author={Aditya Saxena and Barry Denholm and Stephanie Bunt and Marcus Bischoff and Krishnaswamy VijayRaghavan and Helen IeB. Skaer},
  booktitle={PLoS biology},
  year={2014}
}
Most epithelial tubes arise as small buds and elongate by regulated morphogenetic processes including oriented cell division, cell rearrangements, and changes in cell shape. Through live analysis of Drosophila renal tubule morphogenesis we show that tissue elongation results from polarised cell intercalations around the tubule circumference, producing convergent-extension tissue movements. Using genetic techniques, we demonstrate that the vector of cell movement is regulated by localised… CONTINUE READING

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